John Tomich, Ph.D., Professor
Director of Biotechnology/Proteomics Core Facility
Undergraduate Advisor
Contact informationOffice: 206 Burt Hall EducationB.A. 1974, University of Connecticut |
Research video
Areas of specialty
The Tomich laboratory designs and characterizes synthetic peptides for potential uses as drugs or renewable biomaterials. The lab employs a number of biologic, synthetic, analytic and physical methods to make these characterizations.
Read detailed research description
Selected publications
Natarajan, P., Tomich, J. M. Bio-Interactions of Gold and Iron Oxide Nanoparticles : The Role of Experimental Parameters on in vitro and in vivo Interactions Arch. Biochem. Biophys. (2020) 694,108592 doi:10.1016/j.abb.2020.108592.
Natarajan, P., Roberts, J., Kunte, N., Hunter, W. B., Fleming, S., Tomich, J. M., Avila, L. A. (2020) Cellular Uptake Mechanisms Of Branched Amphiphilic Peptide Capsules Probed with Hollow Water Filled and Magnetic Core Nanospheres. Mol Pharm. 2020 17(6) 2208–2220 doi:10.1021/acs.molpharmaceut.0c00393. PMID:32324415
Wessel, E. M., Tomich, J. M., Todd, R. B. Biodegradable Drug-Delivery Peptide Nano-Capsules ACS-Omega 2019 4, 22, 20059–20063. doi:10.1021/acsomega.9b03245. PMID:31788640
Hunter, W. B., Gonzalez, M. T., Tomich, J. M. (2018) BAPC-assisted CRISPR/Cas9 System: Targeted Delivery into Adult Ovaries for Heritable Germline Gene Editing (Arthropoda: Hemiptera) bioRxiv 478743; doi:10.1101/478743
Avila, L.A., Chandrasekar, R., Wilkinson, K. E. Balthazor, J., Herman, M., Bechard, J., Brown, S., Park, Y., Dhar, S., Reeck, G.R., Tomich, J. M. Delivery of lethal dsRNAs in insect diets by Branched Amphiphilic Peptide Capsules. J. Control Release (2018) 273, 139-146. doi: 10.1016/j.jconrel.2018.01.010. PMID:29407675
Barros, S. M., Avila, L. A., Whitaker, S. K., Sukthankar, P., Beltrão, E. I. C., Tomich, J. M. (2017) Branched Amphipathic Peptide Capsules: Different Ratios of the Two Constituent Peptides Direct Distinct Bilayer Structures and Sizes. Langmuir. 33(28):7096-7104. doi: 10.1021/acs.langmuir.7b00912. PMID:28654272
Barros, S. M., Whitaker, S. K., Sukthankar, P. R., Gudlur, S., Warner, M. Beltrão, E. I. C., Tomich, J.M. (2016) A Review of Solute Encapsulating Nanoparticles used as Delivery Systems with Emphasis on Branched Amphipathic Peptide Capsules. Arch Biochem Biophys. 596: 22-42. PMID: 26926258
Sukthankar, P, Whitaker, S.K., Garcia, M., Herrera, A., Boatwright, M., Prakash, O., and Tomich, J.M. (2015) Thermally Induced Conformational Transitions in Nascent Branched Amphiphilic Peptide Capsules. Langmuir. 2015 Mar 17;31(10):2946-55. doi: 10.1021/la504381y. Epub 2015 Mar 6. PMID: 2571959
Avila, L.A., Aps, L. R. M. M., Sukthankar, P., Ploscariu, N., Gudlur, G., Šimo,L. Szoszkiewicz, R., Park, Y., Lee, S. W., Iwamoto, T., Ferreira, L., Tomich, J. M. (2015) Alternate supramolecular structures for different ratios of branched amphiphilic cationic peptide /DNA assemblies: Correlation with gene delivery. Mol Pharm. 12(3):706-15. PMID: 25647162
Sukthankar, P., Avila, LA., Whitaker, SK., Iwamoto, T., Morgenstern, A., Apostolidis, C., Liu, K., Hanzlik, RP., Dadachova, E., and Tomich, JM. (2014) Branched Amphiphilic Peptide Capsules: Cellular Uptake and Retention of Encapsulated Solutes. Biochim, Biophys. Acta, Biomembranes 1838: 2296-2305. PMID: 24565797.
Chen, J., and Tomich, JM. (2014) Free Energy Analysis of Conductivity and Charge Selectivity of M2GlyR-Derived Synthetic Channels. Biochim, Biophys. Acta, Biomembranes 2014 Sep; 1838 (9):2319-25. PMID: 24582709.
Sukthankar, P., Gudlur, S., Avila, L.A., Whitaker, S., Katz, B.B., Hiromasa, Y., Gao, J., Thapa, P., Moore, D., Iwamoto, T., Tomich, J.M. (2013) Branched Oligopeptides Form Nano-Capsules with Lipid Vesicle Characteristics Langmuir 29:14648−14654. PMC3889211
Gudlur, S., Sukthankar, P., Gao, J. Avila, L.A., Hiromasa, Y., Chen, J., Iwamoto, T., Tomich, J.M. (2012) Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides. PLOS ONE. 7 (9) e45374 pages 1-11 PMC3445502