Stella Y. Lee, Assistant Professor

Contact information

308 Ackert Hall
(785) 532-3446
sylee@ksu.edu

Lab website: http://www.k-state.edu/leelab

Education

Ph.D. 2000, Dalhousie University, Canada. Biology.

Area(s) of Specialization

Intracellular protein transport in health and diseases; Lysosomal storage disorders; Neuronal ceroid lipofuscinosis

Research Focus

We are interested in intracellular protein transport in general. We have recently identified a negative regulator that modulates the COPI-mediated retrograde transportfrom Golgi to ER. Besides the fundamental research, we are also interested in understanding the mechanisms behind transport defects in diseases. Currently we are focusing on one particular type of lysosomal storage disorders, Neuronal-Ceroid Lipofuscinosis.

Selected Publications

Adams, J., Feuerborn, M., Molina, J.A., Wilden, A.R., Adhikari, B., Budden, T., and S. Y. Lee. 2019. Autophagy-lysosome pathway alterations and alpha-synuclein up-regulation in the subtype of neuronal ceroid lipofuscinosis, CLN5 disease. Sci Rep. 9: 151. doi: 10.1038/s41598-018-36379-z.

Adhikari, B., De Silva, B., Molina JA, Allen A, Peck SH, and S. Y. Lee. 2019. Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. Biochim Biophys Acta Mol Basis Dis. 1865: 322-328.

Wilden A. R., Molina, J. A., Feuerborn, M., Boyle, D., and S. Y. Lee. 2018. Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition. Biochim Biophys Acta. Mol Cell Res. 1865: 1356-1367.

De Silva, B., Adams, J., and S.Y. Lee. 2015. Proteolytic processing of the neuronal ceroid lipofuscinosis related lysosomal protein CLN5. Exp. Cell Res. 338:45-53. doi: 10.1016/j.yexcr.2015.08.021.

Moharir, A., Peck, S.H., Budden, T., and S.Y. Lee. 2013. The Role of N-Glycosylation in Folding, Trafficking, and Functionality of Lysosomal Protein CLN5. PLoS ONE 8(9): e74299. doi:10.1371/journal.pone.0074299.

Hsu, V. W., S.Y. Lee, and J.S.Yang. 2009. The evolving understanding of COPI vesicle formation. Nat. Rev. Mol. Cell Biol. 10, 360-364.

Zhang, L.*, S.Y. Lee*, G.V. Beznoussenko, P.J. Peters, J.S. Yang, H.Y. Gilbert, A.L. Brass, S.J. Elledge, S.N. Isaacs, B. Moss, A. Mironov, and V.W. Hsu. 2009. A role for the host coatomer and KDEL receptor in early vaccinia biogenesis. Proc. Natl. Acad. Sci. USA 106: 163-168. (*equal contributions)

View the complete publication list in NCBI