Division of Biology

Sherry Fleming, Professor

fleming

Contact information

18A Ackert Hall
(785) 532-6130
sdflemin@ksu.edu

Lab website: http://www.k-state.edu/fleminglab

Education

Ph.D. 1998, University of Colorado Health Science Center. Immunology.

Area(s) of Specialization

Innate immune response

Research Focus

The focus of my laboratory is on the complement system, natural antibodies and other innate immune molecules in autoimmunity. Although beneficial during infections, these molecules can cause excessive tissue damage during trauma, ischemia/reperfusion and autoimmunity. We have examined the damaging aspects of the innate immune response in multiple models of tissue injury with an emphasis on intestinal ischemia/reperfusion. With the development of therapeutic peptides, we are focusing on the role of beta2 glycoprotein I in multiple models of tissue injury.

Selected Primary Publications

Regal JF, Burwick RM, Fleming SD. 2017. The Complement System and Preeclampsia. Curr Hypertens Rep 19(11):87. doi: 10.1007/s11906-017-0784-4.

Regal JF, Dornfeld KJ, Fleming SD. 2016. Radiotherapy: killing with complement. Ann Transl Med 4(5):94. doi: 10.21037/atm.2015.12.46.

Regal JF, Strehlke ME, Peterson JM, Wing CR, Parker JE, Nieto NF, Bemis LT, Gilbert JS, Fleming SD. 2016. Role of IgM and angiotensin II Type I receptor autoantibodies in local complement activation in placental ischemia-induced hypertension in the rat. Mol Immunol 78:38-47. doi: 10.1016/j.molimm.2016.08.016.

Goering J, Pope MR, Fleming SD. 2016. TLR2 Regulates Complement-Mediated Inflammation Induced by Blood Loss During Hemorrhage. Shock 45(1):33-9. doi: 10.1097/SHK.0000000000000477.

Slone EA, Pope MR, Fleming SD. 2015. Phospholipid scramblase 1 is required for B2-glycoprotein I binding in hypoxia and reoxygenation-induced endothelial inflammation. J Leukoc Biol 98(5):791-804. doi: 10.1189/jlb.3A1014-480R.

Pope MR, Fleming SD. 2015. TLR2 modulates antibodies required for intestinal ischemia/reperfusion-induced damage and inflammation. J Immunol 194(3):1190-8. doi: 10.4049/jimmunol.1303124.

View the complete publication list in NCBI