Maureen Gorman, Ph.D., Research Associate Professor
Complete Publications List
2020s
Weber, J.J., Geisbrecht, B.V., Kanost, M.R., Gorman, M.J. (2024) A conserved asparagine residue stabilizes iron binding in Manduca sexta transferrin-1. Insect Biochemistry and Molecular Biology 168: 104109. doi.org/10.1016/j.ibmb.2024.104109.
Gorman, M.J. (2023) Iron homeostasis in insects. Annual Review of Entomology 68: 51-67. doi.org/10.1146/annurev-ento-040622-092836.
Weber, J.J., Brummett, L.M., Coca, M.E., Tabunoki, H., Kanost, M.R., Ragan, E.J., Park, Y., and Gorman, M.J. (2022) Phenotypic analyses, protein localization, and bacteriostatic activity of Drosophila melanogaster transferrin-1. Insect Biochemistry and Molecular Biology 147: 103811. doi: 10.1016/j.ibmb.2022.103811.
Weber, J.J., Kashipathy, M.M., Battaile, K.P., Go, E., Desaire, H., Kanost, M.R., Lovell, S., and Gorman, M.J. (2020) Structural insight into the novel iron-coordination and domain interactions of transferrin-1 from a model insect, Manduca sexta. Protein Science, Nov 16. doi: 10.1002/pro.3999.
Weber, J.J., Kanost M.R., and Gorman, M.J. (2020) Iron binding and release properties of transferrin-1 from Drosophila melanogaster and Manduca sexta: implications for insect iron homeostasis. Insect Biochemistry and Molecular Biology 125: 103438. doi: 10.1016/j.ibmb.2020.103438.
Noh, M.Y., Kim, S.H., Gorman, M.J., Kramer, K.J., Muthukrishnan, S., and Arakane, Y. (2020) Yellow-g and Yellow-g2 proteins are required for egg desiccation resistance and temporal pigmentation in the Asian tiger mosquito, Aedes albopictus. Insect Biochemistry and Molecular Biology 122: 103386.
Najera, D.G, Dittmer, N.T., Weber, J.J., Kanost, M.R., and Gorman, M.J. (2020) Phylogenetic and sequence analyses of insect transferrins suggest that only transferrin 1 has a role in iron homeostasis. Insect Science, Mar 31;. doi: 10.1111/1744-7917.12783.
Tabunoki, H., Dittmer, N.T., Gorman, M.J., and Kanost, M.R. (2019) Development of a new method for collecting hemolymph and measuring phenoloxidase activity in Tribolium castaneum . BMC Research Notes 12:7.
2010s
Brummett, L.M., Kanost, M.R., and Gorman, M.J. (2017) The immune properties of Manduca sexta transferrin. Insect Biochemistry and Molecular Biology 81: 1-9.
Tabunoki, H., Gorman, M.J., Dittmer, N.T., and Kanost, M.R. (2016) Superoxide dismutase 2 knockdown leads to defects in locomotor activity, sensitivity to paraquat, and increased cuticle pigmentation in Tribolium castaneum . Scientific Reports 6:29583. DOI: 10.1038/srep29583
Peng, Z., Dittmer, N.T., Lang, M., Brummett, L.M., Braun, C.L., Davis, L.C., Kanost, M.R., and Gorman, M.J. (2015) "Multicopper oxidase-1 orthologs from diverse insect species have ascorbate oxidase activity" Feb 17;59C:58-71. doi: 10.1016/j.ibmb.2015.02.005.
Peng, Z., Green, P.G., Arakane, Y., Kanost, M.R., and Gorman, M.J. (2014) A multicopper oxidase-related protein is essential for insect viability, longevity and ovary development. PloS ONE 9: e111344.
Lang, M., Braun, C.L., Kanost, M.R., and Gorman, M.J. (2012) Multicopper oxidase-1 is a ferroxidase essential for iron homeostasis in Drosophila melanogaster. Proceedings of the National Academy of Sciences, USA doi: 10.1073/pnas.1208703109.
Lang, M., Kanost, M.R., and Gorman, M.J. (2012) Multicopper oxidase-3 is a laccase associated with the peritrophic matrix of Anopheles gambiae. PLoS One 7: e33985.
Keshar, P., Nguyen, T.D.T., Gorman, M.J. Barrigan, L.M., Peng, Z., Kanost, M.R., Syed, L.U., Li, J., Zhu, K.Y., and Hua, D.H. (2012) Redox Potentials, laccase oxidation, and antilarval activities of substituted phenols. Bioorganic & Medicinal Chemistry 20: 1679-1689.
Gorman, M.J., Sullivan, L.I., Nguyen, T.D.T., Dai, H., Dittmer, N.T., Syed, L.U., Li, J., Hua, D.H., and Kanost, M.R. (2012) Kinetic properties of alternatively spliced isoforms of laccase-2 from Tribolium castaneum and Anopheles gambiae. Insect Biochem. and Mol. Biol. 42,193-202.
Gorman, M.J., and Arakane, Y. (2010) Tyrosine hydroxylase is required for cuticle sclerotization and pigmentation in Tribolium castaneum. Insect Biochemistry and Molecular Biology 40: 267-273.
2000s
Dittmer, N.T., Gorman, M.J., and Kanost, M.R. (2009) Characterization of endogenous and recombinant forms of laccase-2, a multicopper oxidase from the tobacco hornworm, Manduca sexta. Insect Biochemistry and Molecular Biology 39: 596-606.
Gorman MJ, Dittmer NT, Marshall JL, and Kanost MR (2008) Characterization of the multicopper oxidase gene family in Anopheles gambiae . Insect Biochem. Molec. Biol. 38, 817-824.
Kanost, M.R., and Gorman, M.J. (2008) Phenoloxidases in insect immunity. In Insect Immunology (N. Beckage, ed), Academic Press/Elsevier, San Diego, pp. 69-96.
Gorman, M.J., An, C., and Kanost, M.R. (2007) Characterization of tyrosine hydroxylase from Manduca sexta. Insect Biochemistry and Molecular Biology 37: 1327-1337.
Gorman, M.J., Wang, Y., Jiang, H., and Kanost, M.R. (2007) Manduca sexta hemolymph proteinase 21 activates prophenoloxidase activating proteinase 3 in an insect innate immune response proteinase cascade. Journal of Biological Chemistry 282: 11742-11749.
Gorman, M.J., P. Kankanala, and Kanost, M.R. (2004) Bacterial challenge stimulates innate immune responses in extra-embryonic tissues of tobacco hornworm eggs. Insect Molecular Biology 13:19-24.
Dittmer, N.T., R.J. Suderman, H. Jiang, Y.C. Zhu, M.J. Gorman, K.J. Kramer, and Kanost, M.R. (2004) Characterization of cDNAs encoding putative laccase-like multicopper oxidases and developmental expression in the tobacco hornworm, Manduca sexta, and the malaria mosquito, Anopheles gambiae. Insect Biochemistry and Molecular Biology 34: 29-41.
Zhu, Y., Y. Wang, M.J. Gorman, H. Jiang, and Kanost, M.R. (2003) Manduca sexta serpin-3 regulates prophenoloxidase activation in response to infection by inhibiting prophenoloxidase-activating proteinases. Journal of Biological Chemistry 278: 46556-46564.
Gorman, M.J., and Paskewitz, S.M. (2001) Serine proteases as mediators of mosquito immune responses. Insect Biochemistry and Molecular Biology 31: 257-262.
Gorman, M.J., O.V. Andreeva, and S.M. Paskewitz (2000) Sp22D: a multidomain serine protease with a putative role in insect immunity. Gene 251: 9-17.
Gorman, M.J., and Paskewitz, S.M. (2000) Persistence of infection in mosquitoes injected with bacteria. Journal of Invertebrate Pathology 75: 296-297.
Gorman, M.J., O.V. Andreeva, and Paskewitz, S.M. (2000) Molecular characterization of five serine protease genes cloned from Anopheles gambiae hemolymph. Insect Biochemistry and Molecular Biology 30: 35-46.
1990s
Paskewitz, S.M., S. Reese-Stardy, and Gorman, M.J. (1999) An easter-like serine protease from Anopheles gambiae exhibits changes in transcript abundance following immune challenge. Insect Molecular Biology 8: 329-337.
Paskewitz, S.M., and Gorman, M.J. (1999) Mosquito immunity and malaria parasites. American Entomologist 45: 80-94.
Gorman, M.J., A.M. Schwartz, and Paskewitz, S.M. (1998) The role of surface characteristics in eliciting humoral encapsulation of foreign bodies in Plasmodium-refractory and -susceptible strains of Anopheles gambiae. Journal of Insect Physiology 44: 947-954.
Han, Y.S., C.E. Salazar, S.R. Reese-Stardy, A.J. Cornel, M.J. Gorman, F.H. Collins, and Paskewitz, S.M. (1997) Cloning and characterization of a serine protease from the human malaria vector, Anopheles gambiae. Insect Molecular Biology 6: 385-395.
Gorman, M.J., D.W. Severson, A.J. Cornel, F.H. Collins, and Paskewitz, S.M. (1997) Mapping a quantitative trait locus involved in melanotic encapsulation of foreign bodies in the malaria vector, Anopheles gambiae. Genetics 146: 965-971.
Gorman, M.J., and Paskewitz, S.M. (1997) A genetic study of a melanization response in Plasmodium-refractory and -susceptible strains of Anopheles gambiae. American Journal of Tropical Medicine and Hygiene 56: 446-451.
Gorman, M.J., A.J. Cornel, F.H. Collins, and Paskewitz, S.M. (1996) A shared genetic mechanism for melanotic encapsulation of CM-Sephadex beads and a malaria parasite, Plasmodium cynomolgi B, in the mosquito, Anopheles gambiae. Experimental Parasitology 84: 380-386.
Gorman, M.J., and Kaufman, T.C. (1995) Genetic analysis of embryonic cis-acting elements of the Drosophila homeotic gene Sex combs reduced. Genetics 140: 557-572.
Flory, N., M. Gorman, P.M. Coutino, C. Ford, and Reilly, P.J. (1994) Thermosensitive mutants of Aspergillus awamori glucoamylase by random mutagenesis: inactivation kinetics and structural interpretation. Protein Engineering 7: 1005-1012.
Gorman, M., and Girton, J. (1992) Genetic analysis of deltex and its interaction with the Notch locus in Drosophila melanogaster. Genetics 131:99-112.