Department of Chemistry

Publications

  1. Zhou, Q., Wu, W., Jia, K., Qi, G., Sun, X.S., Li, P.* Design and characterization of PROTAC degraders specific to protein N-terminal methyltransferase 1. Eur. J. Med. Chem. 2022, 244: 114830, DOI: 10.1016/j.ejmech.2022.114830.
  2. Li, Q., Qi, G., Lutter, D., Beard, W., Souza, C.R., Highland, M.A., Wu, W., Li, P., Zhang, Y., Atala, A., Sun, X.S. Injectable peptide hydrogel encapsulation of mesenchymal stem cells improved viability, stemness, anti-inflammatory effects, and early stage wound healing. Biomolecules 2022, 12: 1317, DOI: 10.3390/biom12091317.
  3. Pradyawong, S., Shrestha, R., Li, P., Sun, X.S., and Wang, D. Effect of pH and pH-shifting on lignin–protein interaction and properties of lignin-protein polymers. J. Polym. Environ. 2022, 30, 1908-1919, DOI: 10.1007/s10924-021-02319-8.
  4. Shrestha, R., Jia, K., Khadka, S., Eltis, L.D., and Li, P.* Mechanistic insights into DyPB from Rhodococcus jostii RHA1 via kinetic characterization, ACS Catal. 2021, 11, 5486-5495, DOI: 10.1021/acscatal.1c00703.
  5. Jia, K., Huang, G., Wu, W., Shrestha, R., Wu, B., Xiong, Y., and Li, P.* In vivo methylation of OLA1 revealed by activity-based target profiling of NTMT1, Chem. Sci. 2019, 10, 8094-8099, DOI: 10.1039/C9SC02550B.
    *Highlighted as a back-cover article .
  6. Shrestha, R., Huang, G., Meekins, D., Geisbrecht, B.V., and Li, P.* Mechanistic insights into dye-decolorizing peroxidase revealed by solvent isotope and viscosity effects, ACS Catal. 2017, 7, 6352-6364, DOI: 10.1021/acscatal.7b01861.
  7. Huang, G., Shrestha, R., Jia, K., Geisbrecht, B.V., and Li, P.* Enantioselective synthesis of dilignol model compounds and their stereodiscrimination study with a dye-decolorizing peroxidase, Org. Lett., 2017, 19, 1820-1823, DOI: 10.1021/acs.orglett.7b00587.
  8. Shrestha, R., Chen, X., Ramyar, K. X., Hayati, Z., Carlson, E. A., Bossmann, S. H., Song, L., Geisbrecht, B.V., and Li, P.* Identification of surface-exposed protein radicals and a substrate oxidation site in A-class dye-decolorizing peroxidase from Thermomonospora curvata, ACS Catal. 2016, 6, 8036-8047, DOI: 10.1021/acscatal.6b01952.
  9. Jia, K., Cao, R., Hua, D.H., and Li, P.* Study of class I and class III polyhydroxyalkanoate (PHA) synthases with substrates containing a modified side chain, Biomacromolecules 2016, 17, 1477-1485, DOI: 10.1021/acs.biomac.6b00082.
  10. Udukala, D.N., Wang, H.W., Wendel, S.O., Malalasekera, A.P., Samarakoon, T.N., Yapa, A.S., Abayaweera, G., Basel, M.T., Maynez, P., Ortega, R., Toledo, Y., Bossmann, L., Robinson, C., Janik, K.E., Koper, O.B., Li, P., Motamedi, M., Higgins, D.A., Gadbury, G., Zhu, G.H., Troyer, D.L., and Bossmann, S.H. Early breast cancer screening using iron/iron oxide-based nanoplatforms with sub-femtomolar limits of detection, Beilstein J. Nanotechnol. 2016, 3, 364-373, DOI:10.3762/bjnano.7.33.
  11. Madera, R., Gong, W., Wang, L., Burakova, Y., Lleellish, K., Galliher-Beckley, A., Nietfeld, J., Henningson, J., Jia, K., Li, P., Bai, J., Schlup, J., McVey, S., Tu, C., and Shi, J. Pigs immunized with a novel E2 subunit vaccine are protected from subgenotype heterologous classical swine fever virus challenge, BMC Vet. Res. 2016, 12:197, DOI: 10.1186/s12917-016-0823-4.
  12. Chen, C., Shrestha, R., Jia, K., Gao, P.F., Geisbrecht, B.V., Bossmann, S. H., Shi, J., and Li, P.* Characterization of dye-decolorizing peroxidase (DyP) from Thermomonospora curvata reveals unique catalytic properties of A-type DyPs, J. Biol. Chem. 2015, 290, 23447-23463, DOI: 10.1074/jbc.M115.658807.
  13. Chen, C., Cao, R., Shrestha, R., Ward, C., Katz, B.B., Fischer, C.J., Tomich, J.M. and Li, P.* Trapping of intermediates with substrate analog HBOCoA in the polymerizations catalyzed by class III polyhydroxybutyrate (PHB) synthase from Allochromatium Vinosum, ACS Chem. Biol. 2015, 10, 1330-1339, DOI: 10.1021/cb5009958.
  14. Zhang, W., Chen, C., Cao, R., Maurmann, L., and Li, P.* Inhibitors to polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications, ChemBioChem 2015, 16, 156-166, DOI: 10.1002/cbic.201402380.
  15. Zhang, W., Shrestha, R., Buckley, R. M., Jewell, J., Bossmann, S. H., Stubbe, J., and Li, P.* Mechanistic insight with HBCH2CoA as a probe to polyhydroxybutyrate (PHB) synthases, ACS Chem. Biol. 2014, 9, 1773-1779, DOI: 10.1021/cb5002735.
  16. Wang, H.W., Udukala, D.N., Samarakoon, T.N., Basel, M.T., Kalita, M., Abayaweera, G., Manawadu, H., Malalasekera, A., Robinson, C., Villanueva, D., Maynez, P., Bossmann, L., Riedy, E., Barriga, J., Wang, N., Li, P., Higgins, D.A., Zhu, G., Troyer, D.L., and Bossmann, S.H. Nanoplatforms for highly sensitive fluorescence detection of cancer-related proteases, Photochem. Photobiol. Sci. 2014, 13, 231-240, DOI: 10.1039/c3pp50260k.
  17. Wang, H.W., Shrestha, T.B., Basel, M.T., Dani, R.K., Seo, G.M., Balivada, S., Pyle, M.M., Prock, H., Koper, O.B., Thapa, P.S.; Morre, D., Li, P.; Chikan, V., Troyer, D.L., and Bossmann, S.H. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages,Beilstein J. Nanotechnol. 2012, 3, 444-455, DOI: 10.3762/bjnano.3.51.
  18. Li, P.; Chakraborty, S and Stubbe, J. “Detection of Covalent and Non-covalent Intermediates in the Polymerization Reaction Catalyzed by a C149S Class III Polyhydroxybutyrate Synthase.” Biochemistry,2009, 9202-9211.
  19. Li, P.; Sergueeva, Z. A. and Shaw, B. R. “Nucleoside and Oligonucleoside Boranophosphates: Chemistry and Properties.” Chem. Rev. 2007, 4746-4796.
  20. Li, P.; Xu, Z.; Liu, H. Y.; Wennefors, C. K.; Dobrikov, M.; Ludwig, J.; Shaw, B. R. “Synthesis of a-P-Modified Nucleoside Diphosphates with Ethylenediamine.” J. Am. Chem. Soc. 2005, 16782-16783.
  21. Li, P. and Shaw, B. R. “Synthesis of Nucleoside Boranophosphoramidate Prodrugs Conjugated with Amino Acids.” J. Org. Chem. 2005, 70, 2171-2183.
  22. Li, P. and Shaw, B. R. “Convenient Synthesis of Nucleoside Borane Diphosphate Analogues: Deoxy- and Ribonucleoside 5’-Pa-Boranodiphosphates” J. Org. Chem. 2004, 69, 7051-7057.
  23. Shen, Y. C. and Li, P. “Stereoselective Synthesis of Trifluoromethylated Vinyl- and Dienylphosphonates with g-Alkoxycarbonyl Moiety” J. Fluorine Chem. 2004, 125, 63-66.
  24. Li, P.; Dobrikov, M.; Liu, H. Y. and Shaw, B. R. “Synthesis and Substrate Properties of Acyclothymidine Triphosphate and a-P-Boranotriphosphate for Retroviral Reverse Transcriptase.” Org. Lett. 2003, 5, 2401-2403.
  25. Li, P. and Shaw, B. R. “Synthesis of Nucleoside 3¢,5¢-Cyclic Boranophosphoro­thioates – A New Type of Cyclic Nucleotides.” Chem. Commun. 2002, 2890-2891.
  26. Li, P. and Shaw, B. R. “Synthesis of Prodrug Candidates: Conjugates of Amino Acid with Nucleoside Boranophosphate.” Org. Lett. 2002, 4, 2009-2012.
  27. Shen, Y. C.; Li, P.; Ni, J. H. and Sun, J. “A Novel Double Olefination. Highly Stereoselective Synthesis of Trifluoromethylated 1,3-Butadienylphosphonates.” J. Org. Chem. 1998, 63, 9396-9398.