Pathogens, Toxins, Etc.
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A |
B |
C |
D |
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1 |
Controlled By Regulation: |
Select Agent 42CFR72.7 |
Export Regs15CFR774, |
USDA-APHIS 7CFR331.2; 9CFR121.2(a)(b) |
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2 |
Human pathogens, zoonoses, & "toxin" (EAR ECN 1C351) All vaccines and " immunotoxins" are excluded from the scope of this entry. See also 1C991 |
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3 |
Viruses |
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4 |
Chikungunya virus |
no |
yes |
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5 |
Crimean-Congo haemorrhagic fever virus |
yes |
yes |
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6 |
Dengue fever virus |
no |
yes |
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7 |
Eastern Equine Encephalitis virus |
yes |
yes |
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8 |
Ebola viruses |
yes |
yes |
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9 |
Equine Morbillivirus ( Hendra Virus |
yes |
yes |
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10 |
Japanese encephalitis virus |
no |
yes |
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11 |
Kyasanur Forest virus |
no |
yes |
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12 |
Lassa fever virus |
yes |
yes |
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13 |
Louping ill virus |
no |
yes |
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14 |
Lymphocytic choriomeningitis virus |
no |
yes |
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15 |
Marburg virus |
yes |
yes |
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16 |
Monkey Pox |
no |
yes |
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17 |
Murray Valley encephalitis virus |
no |
yes |
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18 |
Nipah virus |
no |
yes |
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19 |
Omsk haemorrhagic fever virus |
no |
yes |
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20 |
Oropouche virus |
no |
yes |
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21 |
Powassan virus |
no |
yes |
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22 |
Pulmonary and renal syndrome- haemorrhagic fever viruses ( Seoul, Dobrava, Puumala, Sin Nombre) |
no |
yes |
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23 |
Rift Valley fever virus |
yes |
yes |
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24 |
Rocio virus |
no |
yes |
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25 |
South American Haemorrhagic fever viruses- Flexal, Guanarito, Junin, Machupo, Sabia |
yes |
yes |
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26 |
St. Louis encephalitis virus |
no |
yes |
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27 |
Tick-borne encephalitis complex viruses |
yes |
yes |
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28 |
Variola major virus (Smallpox virus) |
yes |
yes |
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29 |
Venezuelan Equine Encephalitis virus |
yes |
yes |
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30 |
Viruses causing hantavirus pulmonary syndrome |
yes |
yes |
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31 |
Western equine encephalitis virus |
no |
yes |
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32 |
White pox |
no |
yes |
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33 |
Yellow fever virus |
yes |
yes |
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34 |
Exemptions: Vaccine strains of viral agents ( Junin Virus strain candid #1, Rift Valley fever virus strain MP-12, Venezuelan Equine encephalitis virus strain TC-83, Yellow fever virus strain 17-D) are exempt. |
yes |
no |
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35 |
Bacteria |
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36 |
Bacillus anthracis |
yes |
yes |
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37 |
Brucella abortus, B. melitensis, B. suis |
yes |
yes |
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38 |
Burkholderia (Pseudomonas) mallei |
yes |
yes |
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39 |
Burkholderia (Pseudomonas) pseudomallei |
yes |
yes |
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40 |
Chlamydia psittaci |
no |
yes |
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41 |
Clostridium botulinum |
yes |
yes |
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42 |
Clostridium perfringens, epsilon toxin producting types (Note: does not control Clostridium perfringens strains other than epsilon toxin producing types) |
no |
yes |
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43 |
Enterohaemorrhagic Escherichia coli, serotype 0157 and other verotoxin producing serotypes (does not control nucleic acid sequences assoc with the pathogenicity of E E coli, serotype 0157 etc, except nucleic acid sequences contain coding for the verotoxin |
no |
yes |
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44 |
Francisella tularensis |
yes |
yes |
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45 |
Salmonella typhi |
no |
yes |
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46 |
Shigella dysenteriae |
no |
yes |
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47 |
Yersinia pestis |
yes |
yes |
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48 |
Exemptions: vaccine strains as described in Title 9 CFR, Part 78.1 are exempt. |
yes |
See 1C991,vaccines " immunotoxins" |
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49 |
Rickettsiae |
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50 |
Bartonella quintana ( Rochalimea quintana, Rickettsia quintana) |
no |
yes |
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51 |
Coxiella burnetii |
yes |
yes |
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52 |
Rickettsia prowazekii |
yes |
yes |
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53 |
Rickettsia rickettsii |
yes |
yes |
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54 |
Fungi |
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55 |
Coccidioides immitis |
yes |
no |
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56 |
Toxins |
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57 |
Abrin |
yes |
yes |
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58 |
Aflatoxins |
yes |
yes |
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59 |
Botulinum toxins |
yes |
yes |
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60 |
Cholera toxin |
no |
yes |
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61 |
Clostridium perfringens epsilon toxin |
yes |
yes |
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62 |
Conotoxins |
yes |
yes |
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63 |
Diacetoxyscirpenol |
yes |
no |
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64 |
HT-2 toxin |
no |
yes |
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65 |
Microcystin ( Cyanginosin) |
no |
yes |
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66 |
Modeccin toxin |
no |
yes |
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67 |
Ricin |
yes |
yes |
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68 |
Saxitoxin |
yes |
yes |
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69 |
Shigatoxin |
yes |
yes |
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70 |
Staphylococcal enterotoxins |
yes |
yes |
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71 |
Tetrodotoxin |
yes |
yes |
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72 |
T-2 toxin |
yes |
yes |
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73 |
Verotoxin |
no |
yes |
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74 |
Volkensin toxin |
no |
yes |
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75 |
Viscum Album Lectin 1 ( Viscumin) |
no |
yes |
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76 |
Exemptions: Toxins for medical use, inactivated for use as vaccines, or toxin preparations for biomedical research use at an LD50 for vertebrates of more than 100 nanograms per kilogram body weight are exempt. |
yes |
Vaccines & Immunotoxins, except Cuba, Iran, Libya, NoKorea |
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77 |
Recombinant organisms/molecules |
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78 |
Genetically modified microorganisms or genetic elements from organisms on Appendix A, shown to produce or encode for a factor associated with a disease. |
yes |
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79 |
Genetically modified microorganisms or genetic elements that contain nucleic acid sequences coding for any of the toxins listed in this Appendix, or their toxic subunits. |
yes |
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80 |
Other restrictions |
yes |
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81 |
The deliberate transfer of a drug resistance trait to microorganisms listed in this Appendix that are not known to acquire the trait naturally is prohibited by NIH Guidelines for Research Involving Recombinant |
yes |
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82 |
Animal pathogens (EAR ECN 1C352) |
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83 |
Viruses |
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84 |
African Swine fever virus |
no |
yes |
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85 |
Avian influenza virus that are defined in EC Directive 92/40/EC as: |
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86 |
Type A viruses with an IVPI in 6 week old chickens <1.2 |
no |
yes |
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87 |
Type A viruses H5 or H& subtype for which nucleotide sequencing has demonstrated multiple basic amino acids at the cleavage site of haemagglutinin |
no |
yes |
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88 |
Bluetongue virus |
no |
yes |
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89 |
Foot and mouth disease virus |
no |
yes |
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90 |
Goat pox virus |
no |
yes |
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91 |
Porcine herpes virus ( Aujeszky's disease) |
no |
yes |
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92 |
Swine fever virus (Hog cholera virus) |
no |
yes |
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93 |
Lyssa virus |
no |
yes |
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94 |
Newcastle disease virus |
no |
yes |
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95 |
Peste des petits ruminates virus |
no |
yes |
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96 |
Porcine enterovirus type 9 (swine vesicular disease virus) |
no |
yes |
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97 |
Rinderpest virus |
no |
yes |
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98 |
Sheep pox virus |
no |
yes |
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99 |
Teschen disease virus |
no |
yes |
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100 |
Vesicular stomatitis virus |
no |
yes |
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101 |
Bacteria |
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102 |
Mycoplasma mycoides |
no |
yes |
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103 |
Genetically-modified "microorganisms" (All vaccines are excluded from the scope of this entry) (EAR ECN 1C353) |
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104 |
Genetically modified "microorganisms" or genetic elements that contain nucleic acid sequences associated with pathogenicity of organisms controlled by 1C351.a to .c or 1C352 or 1C354 |
yes |
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105 |
Genetically modified "microorganisms" or genetic elements that contain nucleic acid sequences coding for any of the " toxins" controlled by 1C351.d or "sub-units of toxins" thereof |
yes |
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106 |
Plant Pathogens (All vaccines are excluded) (EAR ECN 1C354) |
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107 |
Xanthomonas albilineans |
no |
yes |
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108 |
Xanthomonas campestris pv. citri including strains referred to as Xanthomonas campestris pv. citri types A, B, C, D, E or otherwise classified as Xanthomonas citri, Xanthomona campestris pv. aurantifolia or Xanthomonas campestris pv. citrumelo |
no |
yes |
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109 |
Fungi |
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110 |
Colletrotrichum coffeanum var. virulans ( Collectotrichum kahawae) |
no |
yes |
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111 |
Cochliobolus miyabeanus ( Helminthosporium oryzae) |
no |
yes |
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112 |
Microcyclus ulei (syn. Dothidella ulei) |
no |
yes |
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113 |
Puccinia graminis (syn. Puccinia graminis f. sp. Tritici) |
no |
yes |
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114 |
Puccinia striformis (syn. Puccinia glumarum) |
no |
yes |
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115 |
Magnaporthe grisea ( pyricularia grisea/pyricularia oryzae) |
no |
yes |
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116 |
Vaccines containing items controlled by ECCNs 1C351, 1C352, 1C353, and 1C354 and immunotoxins (ECN 1C991) License required to ship to Cuba, Iran, Libya and North Korea. |
no |
yes |