News
NOTICE OF AWARD: May 24, 2023
Our collaborative work with the Pusch lab to study ClC-6 and ClC-7 function in endo-lysosomes is now funded via an R21 award from National Institutes of Neurological Disorders and Stroke.
NEW PUBLICATIONS!
Distinct ClC-6 and ClC-7 Cl- sensitivities provide insight into ClC-7’s role in lysosomal Cl- homeostasis, by Maria Antonietta Coppola et al, is the latest collaborative study with Michael Pusch's group in the Institute of Biophysics, Genoa, Italy. The graphical abstract* below summarizes the basic findings published in the December 15th, 2023 issue of The Journal of Physiology.
*Graphical abstract credit: Created with BioRender.com.
You can read the paper by following this link here!
https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/JP285431
This study built on findings of an earlier study, Altered voltage-dependence of slowly activating chloride-proton antiport by late endosomal ClC-6 explains distinct neurological disorders, performed in collaboration with Giovanni Zifarelli and Michael Pusch, and published in The Journal of Physiology
Read it here:
https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP282737
BUT WAIT--THERE'S MORE...
This article was highlighted in a Perspectives piece
Want to hear ClC-6 sing? Push your amp to eleven by the inimitable William Kobertz:
https://physoc.onlinelibrary.wiley.com/doi/epdf/10.1113/JP283060
