November 16, 2020
Michal Zolkiewski to present Anatomy and Physiology Seminar
Michal Zolkiewski, professor and department head of biochemistry and molecular biophysics, will present "Repurposing the Inhibitors of an Anti-Tumor Target in Search for Novel Antimicrobials" at the next Anatomy and Physiology Seminar at 4 p.m. Tuesday, Nov. 17, via Zoom, passcode A&P.
Zolkiewski's research areas of specialty include protein structure and function; protein folding, misfolding and aggregation; AAA+ ATPases in cellular physiology and pathogenesis; molecular chaperones and development of novel antimicrobials.
According to Zolkiewski, "Nearly every process in a living cell is carried out by protein complexes with highly organized structure and undergoing dynamic transformations. Our research is focused on the AAA+ superfamily of proteins. AAA stands for 'ATPases associated with a variety of cellular activities,' which implies that these proteins use energy from ATP and perform a variety of functions. Our laboratory performs basic research oriented toward understanding molecular mechanisms underlying the biological function of AAA+ proteins. We use a combination of biological, biochemical and biophysical experimental approaches to study interactions between proteins, protein localization inside living cells, and structural changes in proteins and protein complexes."